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Keywords:

  • bone fracture;
  • skeletal dysplasia

Abstract

Marshall–Smith syndrome is characterized by accelerated osseous maturation, craniofacial anomalies, failure to thrive, psychomotor delay, hypotonia, pulmonary dysfunction, and limited life expectancy. We describe a 7-year-old girl who, in addition to meeting these criteria for Marshall–Smith syndrome, had multiple fractures and skeletal anomalies. The purpose of this report is to draw attention to Marshall–Smith syndrome as one of the skeletal dysplasias characterized by osseous fragility. © 2003 Wiley-Liss, Inc.