Case-control study of cleft lip or palate after maternal use of topical corticosteroids during pregnancy
Article first published online: 9 APR 2003
Copyright © 2003 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 120A, Issue 4, pages 459–463, 1 August 2003
How to Cite
Edwards, M. J., Agho, K., Attia, J., Diaz, P., Hayes, T., Illingworth, A. and Roddick, L. G. (2003), Case-control study of cleft lip or palate after maternal use of topical corticosteroids during pregnancy. Am. J. Med. Genet., 120A: 459–463. doi: 10.1002/ajmg.a.20130
- Issue published online: 16 JUL 2003
- Article first published online: 9 APR 2003
- Manuscript Accepted: 2 JAN 2003
- Manuscript Received: 30 JUL 2002
- topical corticosteroids;
- cleft lip;
- case-control study;
A case-control survey of 48 children with nonsyndromic cleft lip or palate showed a significant increase in prevalence of maternal use of topical corticosteroid preparations in the first trimester of pregnancy, compared to 58 controls born in the same hospital; the odds ratio was 13.154, 95% confidence interval 1.67–586, P = 0.0049 on Fisher's exact two-tail test. The results were statistically significant although the wide confidence interval reflected the small sample size. Although older epidemiological studies have not detected any association between systemic corticosteroid treatment and the combined incidence of all congenital malformations, experimental studies over several decades have shown that maternal corticosteroid exposure in several species of animals is specifically associated with oral clefts. This association has been confirmed by more specific case-control surveys where the cases were children with cleft lip or palate and the exposure was maternal systemic corticosteroid treatment in the first trimester. Only one previous survey also analyzed topical corticosteroids, and it demonstrated an increased odds ratio for cleft lip or palate. A national survey of children with cleft palate will be necessary to evaluate the results of this pilot study. © 2003 Wiley-Liss, Inc.