Molecular dimensions of gastrointestinal tumors: Some thoughts for digestion


  • M. Michael Cohen, Jr.

    Corresponding author
    1. Departments of Oral & Maxillofacial Sciences, Pediatrics, Community Health & Epidemiology, Health Services Administration, and Sociology & Social Anthropology, Dalhousie University, Halifax, Nova Scotia, Canada
    • Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5.
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Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, β-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal recessive colorectal tumors; STK11 mutations and Peutz-Jeghers syndrome; TGFβ and gastrointestinal cancer; BMPR1A mutations and juvenile polyposis; FGF/FGFR alterations in gastrointestinal neoplasms; PTCH mutations and gastrointestinal neoplasms; RUNX3 expression and gastric cancer; role of mucins in gastric carcinogenesis; KIT, PDGFRα, and gastrointestinal stromal tumors; intestinal neurofibromatosis; and gastrointestinal tumors in other disorders. © 2003 Wiley-Liss, Inc.