Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci
Article first published online: 22 SEP 2004
Copyright © 2004 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 130A, Issue 4, pages 345–350, 1 November 2004
How to Cite
Rioux, J. D., Karinen, H., Kocher, K., McMahon, S. G., Kärkkäinen, P., Janatuinen, E., Heikkinen, M., Julkunen, R., Pihlajamäki, J., Naukkarinen, A., Kosma, V.-M., Daly, M. J., Lander, E. S. and Laakso, M. (2004), Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci. Am. J. Med. Genet., 130A: 345–350. doi: 10.1002/ajmg.a.30072
- Issue published online: 22 OCT 2004
- Article first published online: 22 SEP 2004
- Manuscript Accepted: 6 OCT 2003
- Manuscript Received: 27 MAY 2003
- Bristol-Myers Squibb Company
- Affymetrix, Inc.
- Millennium Pharmaceuticals
- celiac disease;
It has been reported that celiac disease (CD) is strongly associated with the HLA-DQ2 alleles DQA1*0501 and DQB1*0201. However, this association only accounts for a portion of the genetic component of CD. Several non-HLA loci and candidate genes that potentially contribute to CD susceptibility have been reported, but have not been confirmed. The aim of this study was to identify loci that contribute to disease susceptibility in a CD population from Finland. We performed a genomewide linkage scan and identified two regions of significant linkage to CD (6p and 2q23-32) and one region of suggestive linkage (10p). We also performed targeted typing and analyses that replicated the associations of the HLA and CTLA4 loci. © 2004 Wiley-Liss, Inc.