How to cite this article: Hatton DD, Sideris J, Skinner M, Mankowski J, Bailey DB Jr, Roberts J, Mirrett P. 2006. Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP. Am J Med Genet Part A 140A:1804–1813.
Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP†
Article first published online: 12 MAY 2006
Copyright © 2006 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 140A, Issue 17, pages 1804–1813, 1 September 2006
How to Cite
Hatton, D. D., Sideris, J., Skinner, M., Mankowski, J., Bailey, D. B., Roberts, J. and Mirrett, P. (2006), Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP. Am. J. Med. Genet., 140A: 1804–1813. doi: 10.1002/ajmg.a.31286
- Issue published online: 18 AUG 2006
- Article first published online: 12 MAY 2006
- Manuscript Accepted: 27 MAR 2006
- Manuscript Received: 4 NOV 2005
- fragile X syndrome;
- fragile X mental retardation protein
We examined autistic behavior in a cross-sectional sample of 179 children with fragile X syndrome (FXS) and a longitudinal subset of 116 children using the Childhood Autism Rating Scale (CARS) to (a) determine a prevalence of autistic behavior in FXS, (b) examine the stability of autistic ratings over time, and (c) assess the association between the fragile X mental retardation protein (FMRP) and autistic behavior. Approximately 21% of the sample of 129 children (25.9% of boys) scored at or above the cutoff for autism. CARS scores increased slowly, yet significantly, over time, and low levels of FMRP were associated with higher mean levels of autistic behavior as measured by the CARS. © 2006 Wiley-Liss, Inc.