How to cite this article: Thesleff I. 2006. The genetic basis of tooth development and dental defects. Am J Med Genet Part A 140A:2530–2535.
The genetic basis of tooth development and dental defects†
Version of Record online: 12 JUL 2006
Copyright © 2006 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Special Issue: Thirteenth Annual Robert J. Gorlin Conference on Dysmorphology; Facial and Oral Structures: Molecular Perspectives
Volume 140A, Issue 23, pages 2530–2535, 1 December 2006
How to Cite
Thesleff, I. (2006), The genetic basis of tooth development and dental defects. Am. J. Med. Genet., 140A: 2530–2535. doi: 10.1002/ajmg.a.31360
- Issue online: 21 NOV 2006
- Version of Record online: 12 JUL 2006
- Manuscript Accepted: 20 MAY 2006
- Manuscript Received: 1 MAY 2006
- hyopohidrotic ectodermal dysplasia;
- cleidocranial dysplasia;
- EEC syndrome;
More than 300 genes have so far been associated with tooth development, mainly in mouse embryos. The majority of them are associated with conserved signaling pathways mediating cellular communication, in particular between epithelial and mesenchymal tissues. Necessary functions of many signals, receptors and transcription factors have been demonstrated in mice, and mutations causing dental defects in humans have been identified in several genes. © 2006 Wiley-Liss, Inc.