How to cite this article: Cohen MM Jr. 2006. The new bone biology: Pathologic, molecular, and clinical correlates. Am J Med Genet Part A 140A:2646–2706.
The new bone biology: Pathologic, molecular, and clinical correlates†
Article first published online: 13 NOV 2006
Copyright © 2006 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Special Issue: Thirteenth Annual Robert J. Gorlin Conference on Dysmorphology; Facial and Oral Structures: Molecular Perspectives
Volume 140A, Issue 23, pages 2646–2706, 1 December 2006
How to Cite
Cohen Jr., M. M. (2006), The new bone biology: Pathologic, molecular, and clinical correlates. Am. J. Med. Genet., 140A: 2646–2706. doi: 10.1002/ajmg.a.31368
- Issue published online: 21 NOV 2006
- Article first published online: 13 NOV 2006
- Manuscript Accepted: 20 MAY 2006
- Manuscript Received: 1 MAY 2006
- endochondral bone;
- membrane bone;
- WNT signaling;
- cartilaginous tumors;
- bone tumors;
- skeletal dysplasias;
Bone and cartilage and their disorders are addressed under the following headings: functions of bone; normal and abnormal bone remodeling; osteopetrosis and osteoporosis; epithelial–mesenchymal interaction, condensation and differentiation; osteoblasts, markers of bone formation, osteoclasts, components of bone, and pathology of bone; chondroblasts, markers of cartilage formation, secondary cartilage, components of cartilage, and pathology of cartilage; intramembranous and endochondral bone formation; RUNX genes and cleidocranial dysplasia (CCD); osterix; histone deacetylase 4 and Runx2; Ligand to receptor activator of NFκB (RANKL), RANK, osteoprotegerin, and osteoimmunology; WNT signaling, LRP5 mutations, and β-catenin; the role of leptin in bone remodeling; collagens, collagenopathies, and osteogenesis imperfecta; FGFs/FGFRs, FGFR3 skeletal dysplasias, craniosynostosis, and other disorders; short limb chondrodysplasias; molecular control of the growth plate in endochondral bone formation and genetic disorders of IHH and PTHR1; ANKH, craniometaphyseal dysplasia, and chondrocalcinosis; transforming growth factor β, Camurati–Engelmann disease (CED), and Marfan syndrome, types I and II; an ACVR1 mutation and fibrodysplasia ossificans progressiva; MSX1 and MSX2: biology, mutations, and associated disorders; G protein, activation of adenylyl cyclase, GNAS1 mutations, McCune-Albright syndrome, fibrous dysplasia, and Albright hereditary osteodystrophy; FLNA and associated disorders; and morphological development of teeth and their genetic mutations. © 2006 Wiley-Liss, Inc.