Visualization of human prenatal development by magnetic resonance imaging (MRI)

Authors


  • How to cite this article: Shiota K, Yamada S, Nakatsu-Komatsu T, Uwabe C, Kose K, Matsuda Y, Haishi T, Mizuta S, Matsuda T. 2007. Visualization of human prenatal development by magnetic resonance imaging (MRI). Am J Med Genet Part A 143A:3121–3126.

Abstract

It is essential to visualize the structures of embryos and their internal organs three-dimensionally to analyze morphogenesis; this used to rely solely on serial histological sectioning and solid reconstruction, which were tedious and time-consuming. We have applied imaging with a magnetic resonance (MR) microscope equipped with a 2.35 T superconducting magnet to visualize human embryos; we were successful in acquiring high-resolution sectional images and in identifying the detailed structures of major organs. The imaging process was facilitated by using a super-parallel MR microscope. A dataset of MR images of more than 1,000 human embryos, now collected, will be important for future biomedical research and for education. © 2007 Wiley-Liss, Inc.

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