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In utero exposure to mycophenolate mofetil: A characteristic phenotype?†

  1. Antonio Perez-Aytes1,
  2. Ana Ledo1,
  3. Virginia Boso2,
  4. Pilar Sáenz1,
  5. Eva Roma2,
  6. José Luis Poveda2,
  7. Maximo Vento1,*

Article first published online: 11 DEC 2007

DOI: 10.1002/ajmg.a.32117

Issue

American Journal of Medical Genetics Part A

American Journal of Medical Genetics Part A

Volume 146A, Issue 1, pages 1–7, 1 January 2008

Additional Information

How to Cite

Perez-Aytes, A., Ledo, A., Boso, V., Sáenz, P., Roma, E., Poveda, J. L. and Vento, M. (2008), In utero exposure to mycophenolate mofetil: A characteristic phenotype?. Am. J. Med. Genet., 146A: 1–7. doi: 10.1002/ajmg.a.32117

Author Information

  1. 1

    Servicio de Neonatologia, Hospital Universitario Materno-Infantil La Fe, Valencia, Spain

  2. 2

    Servicio de Farmacia, Hospital Universitario Materno-Infantil La Fe, Valencia, Spain

*Professor of Pediatrics, Servicio de Neonatología, Hospital Universitario Materno-Infantil La Fe, Avda. de Campanar, 21, 46009 Valencia, Spain.

  1. †

    How to cite this article: Perez-Aytes A, Ledo A, Boso V, Sáenz P, Roma E, Poveda JL, Vento M. 2007. In utero exposure to mycophenolate mofetil: A characteristic phenotype? Am J Med Genet Part A 146A:1–7.

Publication History

  1. Issue published online: 19 DEC 2007
  2. Article first published online: 11 DEC 2007
  3. Manuscript Accepted: 21 AUG 2007
  4. Manuscript Received: 1 MAR 2007

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REFERENCES

  • Amiel J, Faivre L, Marianowskl R, Bonnet D, Couly G, Manach Y, Le Merrer M, Cormier-Daire V, Munnich A, Lyonnet S. 2001. Hypertelorism-Microtia-Clefting syndrome (Bixler syndrome): Report of two unrelated cases. Clin Dysmorphol 10: 15–18.
  • Armenti VT, Radomski JS, Moritz MJ, Gaughan WJ, Hecker WP, Lavelanet A, McGrory CH, Coscia LA. 2004. Report from the national transplantation pregnancy registry (NTPR): Outcomes of pregnancy after transplantation. Clin Transpl 103–114.
  • CellCept®. 1998. Product information: Roche Pharmaceuticals.
  • Danielsson BRG, Danielsson M, Reiland S, Rundqvist E, Dencker L, Regard CG. 1990. Histological and in vitro studies supporting decreased uteroplacental blood flow as explanation for digital defects after administration of vasodilators. Teratology 41: 158–193.
    Direct Link:
  • Davision JM, Baylis C. 2002. Renal disease. In: de SwietM, editor. Medical disorders in obstetric practice 4e. Malden, MA: Blackwell Science. p 198–266.
  • Dostal A, Nemeckova J, Gaillyova R, Vranova V, Zezulkova D, Lejska M, Slapak I, Dostalova Z, Kuglik P. 2003. Identification of 2.3-Mb gene locus for congenital aural atresia in 18q22.3 deletion: A case report analysed by comparative genomic hybridisation. Otol Neurotol 27: 427–432.
  • EMEA (European Medicines Agency). 2007. CellCept, European public assessment report 2007 (EPAR). http://www.emea.europa.eu/humandocs/Humans/EPAR/cellcept/cellcept.htm (consulted 03/07/07).
  • Jones KL. 2006a. Deletion 18q syndrome. In: JonesKL, editor. Smith's recognizable patterns of human malformation, 6e. Philapelphia: Elsevier Saunders. p 62–63.
  • Jones KL. 2006b. Fetal warfarine syndrome. In: JonesKL, editor. Smith's recognizable patterns of human malformation, 6e. Philapelphia: Elsevier Saunders. p 656–657.
  • Kainz A, Harabacz I, Cowlrick IS, Gadgil SD, Hagiwara D. 2000. Review of the course and outcome of 100 pregnancies in 84 women treated with tacrolimus. Transplantation 70: 1718–1721.
  • Le Ray C, Coulomb A, Elefant E, Frydman R, Audibert F. 2004. Mycophenolate mofetil in pregnancy after renal transplantation: A case of major fetal malformations. Obstet Gynecol 103: 1091–1094.
  • Matesanz R. 2000. El transplante de órganos sólidos en España: éxito de una política. Rev Clin Esp 200: 157–162.
  • McKay DB, Josephson MA. 2006. Pregnancy in recipients of solid organs. Effects on mother and child. N Engl J Med 354: 1281–1293.
  • O'Railly R, Müller F. 1992. Human embryology and teratology. New York: Wiley-Liss. 330 p.
  • Østensen M, Khamashata M, Lockshin M, Parke A, Brucato A, Carp H, Doria A, Rai R, Meroni P, Cetin I, Derksen R, Branch W, Motta M, Gordon C, Ruiz-Irastorza G, Spinillo A, Friedman D, Cimaz R, Czeizel A, Piette JC, Cervera R, Levy RA, Clementi M, De Carolis S, Petri M, Shoenfeld Y, Faden D, Valesini G, Tincani A. 2006. Anti-inflamatory and immunosuppressive drugs and reproduction. Arthritis Res Ther 8: 209 (doi: 10.1186/ar1957).
  • Pérgola PE, Kancharla A, Riley DJ. 2001. Kidney transplantation during the first trimester of pregnancy: Immunosuppression with mycophenolate mofetil, tacrolimus, and prednisone. Transplantation 71: 994–997.
  • Ross L. 2006. Ethical considerations of pregnancy in the female transplant recipient. N Engl J Med 354: 1313–1316.
  • Sanlaville D, Verloes A. 2007. CHARGE syndrome: An update. Eur J Hum Genet 15: 389–399.
  • Sifontis NM, Coscia LA, Constantinescu S, Lavelanet AF, Moritz MJ, Armenti VT. 2006. Pregnancy outcomes in solid organ trasplant recipients with exposure to mycophenolate mofetil or sirolimus. Transplantation 82: 1698–1702.
  • Sinclair A, Baildon R. 2006. Mycophenolate mofetil: An overview. Lupus 15: 70–78.
  • Tendron A, Gouyon JB, Decramer S. 2002. In utero exposure to immunosuppressive drugs: Experimental and clinical studies. Pediatr Nephrol 17: 121–130.
  • Tjeertes IFA, Bastiaans DET, van Ganzewinkel CJML, Zegers SHJ. 2007. Neonatal anemia and hydrops fetalis after maternal mycophenolate mofetil use. J Perinatol 27: 62–64.
  • Veltman JA, Jonkers Y, Nuijten I, Janssen I, van der Vliet W, Huys E, Vermeesch J, Van Buggenhout G, Fryns J-P, Admiraal R, Terhal P, Lacombe D, van Kessel AG, Smeets D, Schoenmakers EFPM, van Ravenswaaij-Arts CM. 2003. Definition of a critical region on chromosome 18 for congenital aural atresia by arrayCGH. Am J Hum Genet 72: 1578–1584.
  • Verloes A. 1994. Hypertelorism-Microtia-Clefting (HMC) syndrome. Gen Couns 5: 283–287.
  • Verloes A. 2005. Updated diagnostic criteria for CHARGE syndrome: A proposal. Am J Med Genet Part A 133A: 306–308.
    Direct Link:
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