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Seizure frequency in adults with Wolf–Hirschhorn syndrome


  • How to cite this article: Worthington JC, Rigby AS, Quarrell OW. 2008. Seizure frequency in adults with Wolf–Hirschhorn syndrome. Am J Med Genet Part A 146A:2528–2531.


Epilepsy is a characteristic feature of Wolf–Hirschhorn syndrome (WHS) with onset usually in the first 2 years of life. There have been several reports of epilepsy ceasing as children get older. We have inspected a register of WHS cases from the UK and identified 27 adults with the condition; their mean age was 24.8 years (range 17–40 years). We conducted a telephone survey and asked parents to comment on their experience of seizures in WHS. In 18 patients (66%) a seizure had not occurred within 3 years. The mean age of those who have been seizure free for over 3 years was 23.7 years (range 17–33 years) whereas for those who had a recent seizure their mean age was 27.1 years (range 17–40 years). The mean age of the last seizure for those who were seizure free for 3 years was 11.3 years (range 2–28 years); in the majority of patients, seizures ceased within childhood years. Many parents commented that seizures were precipitated by fever. Individuals with WHS who had a deletion were more likely to be seizure free than those with a translocation. This reached statistical significance: χ2 = 4.6, P = 0.03, odds ratio = 6.5 (95% CI 1.1–38.6). Data from this survey may be helpful when counseling families with a very young child with WHS. © 2008 Wiley-Liss, Inc.