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New Syndrome

Capillary malformation of the lower lip, lymphatic malformation of the face and neck, asymmetry and partial/generalized overgrowth (CLAPO): Report of six cases of a new syndrome/association†

  1. Juan Carlos López-Gutiérrez1,
  2. Pablo Lapunzina2,3,4,5,*

Article first published online: 16 SEP 2008

DOI: 10.1002/ajmg.a.32517

Issue

American Journal of Medical Genetics Part A

American Journal of Medical Genetics Part A

Volume 146A, Issue 20, pages 2583–2588, 15 October 2008

Additional Information

How to Cite

López-Gutiérrez, J. C. and Lapunzina, P. (2008), Capillary malformation of the lower lip, lymphatic malformation of the face and neck, asymmetry and partial/generalized overgrowth (CLAPO): Report of six cases of a new syndrome/association. Am. J. Med. Genet., 146A: 2583–2588. doi: 10.1002/ajmg.a.32517

Author Information

  1. 1

    Section of Plastic and Reconstructive Surgery, Department of Pediatric Surgery, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain

  2. 2

    Section of Medical Genetics, Instituto de Genética Médica y Molecular, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain

  3. 3

    Section of Molecular Genetics, Instituto de Genética Médica y Molecular, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain

  4. 4

    The Spanish Overgrowth Syndrome Registry, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain

  5. 5

    CIBERER, Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, Madrid, Spain

*Department of Medical and Molecular Genetics, Hospital Universitario La Paz, Autonoma University, Paseo de la Castellana, 261-28046-Madrid, Spain.

  1. †

    How to cite this article: López-Gutiérrez JC, Lapunzina P. 2008. Capillary malformation of the lower lip, lymphatic malformation of the face and neck, asymmetry and partial/generalized overgrowth (CLAPO). Report of six cases of a new syndrome/association. Am J Med Genet Part A 146A:2583–2588.

Publication History

  1. Issue published online: 24 SEP 2008
  2. Article first published online: 16 SEP 2008
  3. Manuscript Accepted: 20 JUN 2008
  4. Manuscript Received: 16 OCT 2007

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Keywords:

  • capillary malformation;
  • lower lip;
  • lymphatic malformation;
  • venous malformation;
  • face;
  • neck;
  • asymmetry;
  • overgrowth;
  • new syndrome;
  • new association

Abstract

We report on six patients with clinical findings consisting of (1) Capillary malformation (CM) of the lower lip; (2) Lymphatic malformation (LM) of the face/neck; (3) Asymmetry of face and limbs, and (4) Partial/ generalized Overgrowth. This constellation of findings has been observed in six unrelated patients, constituting a likely “new” syndrome/association of capillary-lymphatic-venous malformation and asymmetric overgrowth. © 2008 Wiley-Liss, Inc.

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