Capillary malformation of the lower lip, lymphatic malformation of the face and neck, asymmetry and partial/generalized overgrowth (CLAPO): Report of six cases of a new syndrome/association

Authors

  • Juan Carlos López-Gutiérrez,

    1. Section of Plastic and Reconstructive Surgery, Department of Pediatric Surgery, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain
    Search for more papers by this author
  • Pablo Lapunzina

    Corresponding author
    1. Section of Medical Genetics, Instituto de Genética Médica y Molecular, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain
    2. Section of Molecular Genetics, Instituto de Genética Médica y Molecular, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain
    3. The Spanish Overgrowth Syndrome Registry, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain
    4. CIBERER, Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, Madrid, Spain
    • Department of Medical and Molecular Genetics, Hospital Universitario La Paz, Autonoma University, Paseo de la Castellana, 261-28046-Madrid, Spain.
    Search for more papers by this author

  • How to cite this article: López-Gutiérrez JC, Lapunzina P. 2008. Capillary malformation of the lower lip, lymphatic malformation of the face and neck, asymmetry and partial/generalized overgrowth (CLAPO). Report of six cases of a new syndrome/association. Am J Med Genet Part A 146A:2583–2588.

Abstract

We report on six patients with clinical findings consisting of (1) Capillary malformation (CM) of the lower lip; (2) Lymphatic malformation (LM) of the face/neck; (3) Asymmetry of face and limbs, and (4) Partial/ generalized Overgrowth. This constellation of findings has been observed in six unrelated patients, constituting a likely “new” syndrome/association of capillary-lymphatic-venous malformation and asymmetric overgrowth. © 2008 Wiley-Liss, Inc.

Ancillary