How to cite this article: du Souich C, Austin JC, Friedlander R, Boerkoel CF. 2009. A novel syndrome with psychiatric features and review of malformation syndromes with psychiatric disorders. Am J Med Genet Part A 149A:713–721.
A novel syndrome with psychiatric features and review of malformation syndromes with psychiatric disorders†
Version of Record online: 27 FEB 2009
Copyright © 2009 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 149A, Issue 4, pages 713–721, April 2009
How to Cite
du Souich, C., Austin, J. C., Friedlander, R. and Boerkoel, C. F. (2009), A novel syndrome with psychiatric features and review of malformation syndromes with psychiatric disorders. Am. J. Med. Genet., 149A: 713–721. doi: 10.1002/ajmg.a.32709
- Issue online: 24 MAR 2009
- Version of Record online: 27 FEB 2009
- Manuscript Accepted: 12 DEC 2008
- Manuscript Received: 16 MAY 2008
- psychiatric disease;
Psychiatric disease occurs with increased frequency in a number of malformation syndromes. We hypothesize that the study of these disorders is helpful for understanding the pathophysiology of psychiatric disease. With this objective, we have been screening for individuals with malformations and prominent psychiatric disease. We report on a man with visual and auditory hallucinations and behavioral problems who was the product of an incestuous relationship and had anomalies primarily of his face, hands and feet. His distinctive features define an undescribed acro-auricular malformation syndrome with a psychiatric component. The study of Mendelian syndromes such as the one presented will likely be helpful for isolating novel genes involved in psychiatric illness. © 2009 Wiley-Liss, Inc.