How to cite this article: Gaide O. 2009. Gene therapy and protein therapy of ectodermal dysplasias: A Perspective. Am J Med Genet Part A 149A:2042–2044.
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Gene therapy and protein therapy of ectodermal dysplasias: A perspective†
Article first published online: 13 AUG 2009
DOI: 10.1002/ajmg.a.32839
Copyright © 2009 Wiley-Liss, Inc.
Issue
American Journal of Medical Genetics Part A
Special Issue: Ankyloblepharon-Ectodermal Defects-Cleft Lip and/or Palate Syndrome and Ectodermal Dysplasias
Volume 149A, Issue 9, pages 2042–2044, September 2009
Additional Information
How to Cite
Gaide, O. (2009), Gene therapy and protein therapy of ectodermal dysplasias: A perspective. Am. J. Med. Genet., 149A: 2042–2044. doi: 10.1002/ajmg.a.32839
- †
Publication History
- Issue published online: 20 AUG 2009
- Article first published online: 13 AUG 2009
- Manuscript Accepted: 9 MAR 2009
- Manuscript Received: 26 JAN 2009
- Abstract
- Article
- References
- Cited By
Keywords:
- gene therapy;
- biologics;
- ectodermal dysplasia
Abstract
Ectodermal dysplasias (EDs) form a complex and heterogeneous group of diseases currently defined and classified according to their clinical symptoms. The characterization, for several EDs, of the molecular events underlying their development, not only challenges this classification but also opens the door to new therapeutic options such as gene or protein therapy. This article provides a concise overview of the most recent successes and failures of this new type of treatment and sets in perspective how the specificities of given EDs will influence their feasibility in the near future. It makes the case for the need of new classification of EDs that is based on our most recent knowledge of the molecular basis of these diseases. © 2009 Wiley-Liss, Inc.