Editor's Note This report by Tirado and colleagues and the ensuing paper by Vera-Carbonell et al. describe two separate individuals with a distal chromosome deletion accompanied by a more proximal inverted duplication. While this rearrangement and its proposed mechanisms were reported more than 25 years ago, it has been the recent application of FISH and array CGH that has allowed for better characterization of the abnormalities and the elucidation of pathogenetic mechanisms. In addition to these two papers, I draw the reader's attention to the recent article by Rowe et al. in the Journal of Medical Genetics [2009] for an in depth discussion of the mechanism and some of the background. What is now clear is that this rearrangement originally described in 1976 on 8p has been reported in most chromosomes. John C. Carey, MD Editor-in-Chief

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