How to cite this article: Child AH, Gordon KD, Sharpe P, Brice G, Ostergaard P, Jeffery S, Mortimer PS. 2010. Lipedema: An inherited condition. Am J Med Genet Part A 152A:970–976.
Lipedema: An inherited condition†
Article first published online: 26 MAR 2010
Copyright © 2010 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 152A, Issue 4, pages 970–976, April 2010
How to Cite
Child, A. H., Gordon, K. D., Sharpe, P., Brice, G., Ostergaard, P., Jeffery, S. and Mortimer, P. S. (2010), Lipedema: An inherited condition. Am. J. Med. Genet., 152A: 970–976. doi: 10.1002/ajmg.a.33313
- Issue published online: 26 MAR 2010
- Article first published online: 26 MAR 2010
- Manuscript Accepted: 12 DEC 2009
- Manuscript Received: 28 APR 2009
- Bluff-Field Charitable Fund, St. George's, University of London
- St. George's NHS Hospital Trust
- Daphne Jackson Trust
- British Skin Foundation
- autosomal dominant;
- X-linked dominant
Lipedema is a condition characterized by swelling and enlargement of the lower limbs due to abnormal deposition of subcutaneous fat. Lipedema is an under-recognized condition, often misdiagnosed as lymphedema or dismissed as simple obesity. We present a series of pedigrees and propose that lipedema is a genetic condition with either X-linked dominant inheritance or more likely, autosomal dominant inheritance with sex limitation. Lipedema appears to be a condition almost exclusively affecting females, presumably estrogen-requiring as it usually manifests at puberty. Lipedema is an entity distinct from obesity, but may be wrongly diagnosed as primary obesity, due to clinical overlap. The phenotype suggests a condition distinct from obesity and associated with pain, tenderness, and easy bruising in affected areas. © 2010 Wiley-Liss, Inc.