How to Cite this Article: Katzaki E, Morin G, Pollazzon M, Papa FT, Buoni S, Hayek J, Andrieux J, Lecerf L, Popovici C, Receveur A, Mathieu-Dramard M, Renieri A, Mari F, Philip N. 2010. Syndromic mental retardation with thrombocytopenia due to 21q22.11q22.12 deletion: Report of three patients. Am J Med Genet Part A.
Syndromic mental retardation with thrombocytopenia due to 21q22.11q22.12 deletion: Report of three patients†
Version of Record online: 27 MAY 2010
Copyright © 2010 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 152A, Issue 7, pages 1711–1717, July 2010
How to Cite
Katzaki, E., Morin, G., Pollazzon, M., Papa, F. T., Buoni, S., Hayek, J., Andrieux, J., Lecerf, L., Popovici, C., Receveur, A., Mathieu-Dramard, M., Renieri, A., Mari, F. and Philip, N. (2010), Syndromic mental retardation with thrombocytopenia due to 21q22.11q22.12 deletion: Report of three patients. Am. J. Med. Genet., 152A: 1711–1717. doi: 10.1002/ajmg.a.33478
- Issue online: 25 JUN 2010
- Version of Record online: 27 MAY 2010
- Manuscript Accepted: 3 MAR 2010
- Manuscript Received: 2 NOV 2009
- Telethon. Grant Number: GTB07001
- University of Siena. Grant Number: PAR2006
- chromosome 21;
- mental retardation;
- 21q interstitial deletion;
During the last few years, an increasing number of microdeletion/microduplication syndromes have been delineated. This rapid evolution is mainly due to the availability of microarray technology as a routine diagnostic tool. Microdeletions of the 21q22.11q22.12 region encompassing the RUNX1 gene have been reported in nine patients presenting with syndromic thrombocytopenia and mental retardation. RUNX1 gene is responsible for an autosomal dominant platelet disorder with predisposition to acute myelogenous leukemia. We report on three novel patients with an overlapping “de novo” interstitial deletion involving the band 21q22 characterized by array-CGH. All our patients presented with severe developmental delay, dysmorphic features, behavioral problems, and thrombocytopenia. Comparing the clinical features of our patients with the overlapping ones already reported two potential phenotypes related to 21q22 microdeletion including RUNX1 were highlighted: thrombocytopenia with ± mild dysmorphic features and syndromic thrombocytopenia with growth and developmental delay. © 2010 Wiley-Liss, Inc.