How to Cite this Article: Shanske AL. 2010. Introductory comments on special section—New developments in craniofacial biology: Putting on a happy face. Am J Med Genet Part A 152A:2943–2946.
Introductory comments on special section—New developments in craniofacial biology: Putting on a happy face†
Article first published online: 26 AUG 2010
Copyright © 2010 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 152A, Issue 12, pages 2943–2946, December 2010
How to Cite
Shanske, A. L. (2010), Introductory comments on special section—New developments in craniofacial biology: Putting on a happy face. Am. J. Med. Genet., 152A: 2943–2946. doi: 10.1002/ajmg.a.33614
- Issue published online: 23 NOV 2010
- Article first published online: 26 AUG 2010
- Manuscript Accepted: 27 JUN 2010
- Manuscript Received: 24 JUN 2010
- craniofacial abnormalities;
- craniofacial biology;
- signaling pathways;
- neural crest cells;
- retinoic acid;
- Goldilocks phenomenon;
- Treacher Collins syndrome;
- ribosome biogenesis;
- tooth development
Approximately three quarters of children with birth defects have anomalies that affect the craniofacial structures. Defects in this area of the body result in lifelong disability, major challenges to families and society and often a serious effect on life expectancy. Surgery has been the primary intervention for these disorders, with frequently less than optimal outcomes and risk for additional morbidity and mortality. The challenge for clinicians caring for these children is to develop new methods for the treatment and prevention of these disorders. An understanding of the evolution of the head and the finely tuned temporospatial signaling pathways involved is critical to understanding the origins of the vertebrates as well as of human craniofacial malformations. In the future, these new approaches will be based upon our enhanced understanding of the developmental tool kit fashioned by evolution and the application of this knowledge toward the development of new diagnostic, pharmacologic, and genetic interventions for these disorders. © 2010 Wiley-Liss, Inc.