The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention, the National Institute of Child Health and Human Development, the National Institutes of Health, or the California Department of Public Health.
Version of Record online: 14 OCT 2010
Copyright © 2010 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 152A, Issue 11, pages 2756–2761, November 2010
How to Cite
Ma, C., Carmichael, S. L., Scheuerle, A. E., Canfield, M. A. and Shaw, G. M. (2010), Association of microtia with maternal obesity and periconceptional folic acid use. Am. J. Med. Genet., 152A: 2756–2761. doi: 10.1002/ajmg.a.33694
How to Cite this Article: Ma C, Carmichael SL, Scheuerle AE, Canfield MA, Shaw GM, the National Birth Defects Prevention Study. 2010. Association of microtia with maternal obesity and periconceptional folic acid use. Am J Med Genet Part A 152A:2756–2761.
- Issue online: 26 OCT 2010
- Version of Record online: 14 OCT 2010
- Manuscript Accepted: 1 AUG 2010
- Manuscript Received: 10 MAR 2010
- Centers for Disease Control and Prevention. Grant Numbers: U50/CCU925286, U01DD000494-02
- NIH. Grant Number: R03 DE019521
- birth defect;
- risk factor;
- vitamin supplements;
- folic acid;
The study objective was to examine the association of microtia with maternal intake of folic-acid-containing supplements and obesity. The study data included deliveries from 1997 to 2005 from the National Birth Defects Prevention Study. Non-syndromic cases of microtia were compared to non-malformed, population-based liveborn control infants, by estimating adjusted odds ratios (AORs) and 95% confidence intervals (CIs) from logistic regression models that included maternal race/ethnicity, education, and study site. Maternal obesity was only weakly associated with microtia. Maternal periconceptional intake of folic-acid-containing vitamin supplements reduced the risk for microtia, but only among non-obese women (OR: 0.63; 95% CI: 0.44–0.91). The reduced risk was stronger when analyses were restricted to isolated cases (OR: 0.51; 95% CI: 0.34–0.77), and it was independent of the level of maternal dietary folate intake. Adjusting for maternal race/ethnicity did not reveal alternative interpretations of this association. This analysis suggests that maternal periconceptional intake of folic-acid-containing supplements may provide protection from microtia for non-obese women. © 2010 Wiley-Liss, Inc.