How to Cite this Article: Cordero DR, Brugmann S, Chu Y, Bajpai R, Jame M, Helms JA. 2011. Cranial neural crest cells on the move: Their roles in craniofacial development. Am J Med Genet Part A 155:270–279.
Cranial neural crest cells on the move: Their roles in craniofacial development†
Article first published online: 10 DEC 2010
Copyright © 2010 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 155, Issue 2, pages 270–279, February 2011
How to Cite
Cordero, D. R., Brugmann, S., Chu, Y., Bajpai, R., Jame, M. and Helms, J. A. (2011), Cranial neural crest cells on the move: Their roles in craniofacial development. Am. J. Med. Genet., 155: 270–279. doi: 10.1002/ajmg.a.33702
- Issue published online: 25 JAN 2011
- Article first published online: 10 DEC 2010
- Manuscript Accepted: 17 AUG 2010
- Manuscript Received: 8 JUN 2010
- Eunice Kennedy Shriver National Institute of Child Health & Human Development. Grant Number: K12HD001255
- Eleanor and Miles Shore Scholars in Medicine
- National Institute of Health (NIH). Grant Number: K99DEO19853-01
- neural crest cells;
- craniofacial development;
The craniofacial region is assembled through the active migration of cells and the rearrangement and sculpting of facial prominences and pharyngeal arches, which consequently make it particularly susceptible to a large number of birth defects. Genetic, molecular, and cellular processes must be temporally and spatially regulated to culminate in the three-dimension structures of the face. The starting constituent for the majority of skeletal and connective tissues in the face is a pluripotent population of cells, the cranial neural crest cells (NCCs). In this review we discuss the newest scientific findings in the development of the craniofacial complex as related to NCCs. Furthermore, we present recent findings on NCC diseases called neurocristopathies and, in doing so, provide clinicians with new tools for understanding a growing number of craniofacial genetic disorders. © 2010 Wiley-Liss, Inc.