How to Cite this Article: Carmany EP, Bawle EV. 2011. Microduplication of 4p16.3 due to an unbalanced translocation resulting in a mild phenotype. Am J Med Genet Part A 155:819–824.
Microduplication of 4p16.3 due to an unbalanced translocation resulting in a mild phenotype†
Article first published online: 15 MAR 2011
Copyright © 2011 Wiley-Liss, Inc.
American Journal of Medical Genetics Part A
Volume 155, Issue 4, pages 819–824, April 2011
How to Cite
Carmany, E. P. and Bawle, E. V. (2011), Microduplication of 4p16.3 due to an unbalanced translocation resulting in a mild phenotype. Am. J. Med. Genet., 155: 819–824. doi: 10.1002/ajmg.a.33916
- Issue published online: 24 MAR 2011
- Article first published online: 15 MAR 2011
- Manuscript Accepted: 23 DEC 2010
- Manuscript Received: 29 JUL 2010
- pair 4;
- Wolf–Hirschhorn syndrome;
- chromosome duplication;
- microarray analysis;
With the widespread clinical use of comparative genomic hybridization chromosomal microarray technology, several previously unidentified clinically significant submicroscopic chromosome abnormalities have been discovered. Specifically, there have been reports of clinically significant microduplications found in regions of known microdeletion syndromes. In general, these microduplications have distinct features from those described in the corresponding microdeletion syndromes. We present a 5½-year-old patient with normal growth, borderline normal IQ, borderline hypertelorism, and speech and language delay who was found to have a submicroscopic 2.3 Mb terminal duplication involving the two proposed Wolf–Hirschhorn syndrome (WHS) critical regions at chromosome 4p16.3. This duplication was the result of a maternally inherited reciprocal translocation involving the breakpoints 4p16.3 and 17q25.3. Our patient's features are distinct from those described in WHS and are not as severe as those described in partial trisomy 4p. There are two other patients in the medical literature with 4p16.3 microduplications of similar size also involving the WHS critical regions. Our patient shows clinical overlap with these two patients, although overall her features are milder than what has been previously described. Our patient's features expand the knowledge of the clinical phenotype of a 4p16.3 microduplication and highlight the need for further information about it. © 2011 Wiley-Liss, Inc.