How to Cite this Article: Ben Amor IM, Rauch F, Gruenwald K, Weis M, Eyre DR, Roughley P, Glorieux FH, Morello R. 2011. Severe osteogenesis imperfecta caused by a small in-frame deletion in CRTAP. Am J Med Genet Part A 155: 2865–2870.
Severe osteogenesis imperfecta caused by a small in-frame deletion in CRTAP†
Article first published online: 30 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Volume 155, Issue 11, pages 2865–2870, November 2011
How to Cite
Amor, I.M. B., Rauch, F., Gruenwald, K., Weis, M., Eyre, D.R., Roughley, P., Glorieux, F.H. and Morello, R. (2011), Severe osteogenesis imperfecta caused by a small in-frame deletion in CRTAP. Am. J. Med. Genet., 155: 2865–2870. doi: 10.1002/ajmg.a.34269
- Issue published online: 20 OCT 2011
- Article first published online: 30 SEP 2011
- Manuscript Accepted: 17 JUL 2011
- Manuscript Received: 5 JAN 2011
- recessive osteogenesis imperfecta;
- 3-hydroxylation complex;
Mutations of proteins involved in posttranslational modification of collagen type I can cause osteogenesis imperfecta (OI) inherited in a recessive pattern. The cartilage-associated protein (CRTAP) is part of a heterotrimeric complex (together with prolyl-3-hydroxylase-1 [P3H1] and cyclophilin B) that 3-hydroxylates the alpha 1 chain of collagen type I at proline residue 986 and plays a collagen chaperon role. CRTAP mutations usually cause severe OI. We report on a patient with OI and a homozygous in-frame deletion in CRTAP and a severe form of OI. The girl was born with markedly deformed long bones. Despite intravenous bisphosphonate treatment, she developed multiple vertebral compression fractures and severe scoliosis and at 4 years of age was able to sit only with support. Although CRTAP transcript levels were normal in the patient's fibroblasts, protein levels of both CRTAP and P3H1 were severely reduced. The degree of 3-hydroxylation at proline residue 986 was also decreased. This report characterizes a patient with a CRTAP small in-frame deletion. We are unaware of prior reports of this finding. We suggest that this deletion affects crucial amino acids that are important for the interaction and/or stabilization of CRTAP and P3H1. © 2011 Wiley Periodicals, Inc.