How to cite this article: McCandless SE, Powell KP, Sandberg U. 2011. Risk for ingestion of toxic substances in children with Prader–Willi syndrome. Am J Med Genet Part A 158A: 2866–2869.
Risk for ingestion of toxic substances in children with Prader–Willi syndrome†
Article first published online: 14 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Special Issue: SPECIAL ISSUE: GROWTH CHARTS IN GENETIC SYNDROMES
Volume 158A, Issue 11, pages 2866–2869, November 2012
How to Cite
McCandless, S. E., Powell, K. P. and Sandberg, U. (2012), Risk for ingestion of toxic substances in children with Prader–Willi syndrome. Am. J. Med. Genet., 158A: 2866–2869. doi: 10.1002/ajmg.a.34315
- Issue published online: 17 OCT 2012
- Article first published online: 14 SEP 2012
- Manuscript Accepted: 20 AUG 2011
- Manuscript Received: 18 FEB 2010
- Prader–Willi syndrome;
- toxic ingestion
Individuals with Prader–Willi syndrome (PWS) have several common findings that may predispose to ingestion of potentially dangerous items. This study examined whether individuals with PWS have an increased prevalence of toxic ingestions. A survey regarding history of ingestions in PWS individuals and sibling controls was designed, piloted, and distributed on-line. The subjects were individuals with PWS (N = 129). The subjects' non-PWS siblings served as controls (N = 134). Participants who completed the anonymous online survey were either the parents or the primary caretaker of individuals with PWS. Responses were submitted by 141 participants, providing information about 130 PWS subjects (M/F: 66:64) and 134 sibling controls. Subjects and controls ranged in age from 2 to 18 years at the time of the survey. Eleven participants did not answer the questions regarding ingestions. History of toxic ingestion was more prevalent in PWS subjects (20% vs. 2% of controls). Several features of PWS, including history of searching for food and eating unusual objects, along with decreased cognitive ability, appeared to associate with increased prevalence of toxic ingestion in PWS individuals. PWS children appear to have an ∼12-fold increased risk of ingesting toxins compared to the general population. Geneticists should include this information in counseling and in recommendations to primary care providers. Also, poison control centers need to be aware of this association and of the physiological and behavioral aspects of PWS that may complicate the diagnosis and management of a toxic ingestion. © 2012 Wiley Periodicals, Inc.