How to Cite this Article: Bugge M. 2012. Body stalk anomaly in Denmark during 20 years (1970–1989). Am J Med Genet Part A. 158A:1702–1708.
Body stalk anomaly in Denmark during 20 years (1970–1989)†
Article first published online: 31 MAY 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Volume 158A, Issue 7, pages 1702–1708, July 2012
How to Cite
Bugge, M. (2012), Body stalk anomaly in Denmark during 20 years (1970–1989). Am. J. Med. Genet., 158A: 1702–1708. doi: 10.1002/ajmg.a.35394
- Issue published online: 18 JUN 2012
- Article first published online: 31 MAY 2012
- Manuscript Accepted: 1 MAR 2012
- Manuscript Received: 27 DEC 2011
- Fonden til Laegevidenskabens Fremme. Grant Numbers: 15-81, 06020/2006
- Direktoer Jacob Madsen and Hustru Olga Madsens Fond. Grant Number: 4277/2006
- Direktoer Ib Henriksens Fond. Grant Number: i-1931
- Kong Cristian den Tiendes Fond. Grant Number: 108/2006
- Fonden af 17-12-1981
- Broedrene Hartmanns Fond
- body stalk anomaly;
- abdominal wall defect;
- limb-body wall complex
Body stalk anomaly is a severe defect of the abdominal wall with uncovered thoracic and/or abdominal organs. The umbilical cord is absent or very short. Here I present epidemiological and clinical data on 16 infants with body stalk anomaly. The 16 infants represent 3.4% of the 469 infants ascertained in an almost complete nationwide data set of live- and stillborn infants born with abdominal wall defects during the two decades 1970–1989 in Denmark. The prevalence was 0.12 per 10,000 live- and stillborn. Nine of the infants were stillbirths, seven were live births, and they all died shortly after birth. The gestational age at birth varied from 33 to 40 weeks. There was an excess of males M/F ratio: 2.2 (CI: 0.85–10.71). All infants had severe associated malformations. Among the most severe were: severe limb reduction defects (56%), absence of one kidney associated with malformations of genitalia and/or urinary bladder (62%), scoliosis (82%), and anal atresia (57%). A normal karyotype was found in all eight of the infants who were tested. There were two sets of twins; one discordant and one concordant. Mean maternal and paternal ages were 28.5 and 29.5 years, respectively, not significantly different from the mean parental ages of the Danish population during the same period. © 2012 Wiley Periodicals, Inc.