How to Cite this Article: Afifi HH, Aglan MS, Zaki ME, Thomas MM, Tosson AMS. 2012. Growth charts of Down syndrome in Egypt: A study of 434 children 0–36 months of age. Am J Med Genet Part A 158A: 2647–2655.
Growth charts of Down syndrome in Egypt: A study of 434 children 0–36 months of age†
Article first published online: 18 JUL 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Special Issue: SPECIAL ISSUE: GROWTH CHARTS IN GENETIC SYNDROMES
Volume 158A, Issue 11, pages 2647–2655, November 2012
How to Cite
Afifi, H. H., Aglan, M. S., Zaki, M. E., Thomas, M. M. and Tosson, A. M.S. (2012), Growth charts of Down syndrome in Egypt: A study of 434 children 0–36 months of age. Am. J. Med. Genet., 158A: 2647–2655. doi: 10.1002/ajmg.a.35468
- Issue published online: 17 OCT 2012
- Article first published online: 18 JUL 2012
- Manuscript Accepted: 13 APR 2012
- Manuscript Received: 27 NOV 2011
- Down syndrome;
- growth charts;
The aim of the study was to construct new reference growth charts for weight, length and head circumference of Egyptian children with Down syndrome (DS) from birth to 36 months of age. These specific charts may be used by health professionals involved in medical, physical and developmental care of Egyptian children with Down syndrome. The study included 434 children with non-disjunction trisomy 21, 0–36 months of age. They were 54.4% males and 45.6% females and had no concomitant chronic disease (congenital heart disease, gastrointestinal malformations, hypothyroidism, and blood disorders). Overall, 1,955 observations were performed of weight, length and head circumference. The data for each sex were divided into 37 different age groups with 1-month intervals. All measurements were taken using standardized equipments and following the international recommendations. Values were statistically analyzed and growth curves were plotted as means and standard deviations (SD). Growth measurements evaluated in all age groups of both sexes were significantly lower than those of the controls. There was a gender difference in weight, length and head circumference, males with Down syndrome had higher values. In conclusion, we suggest that these new growth charts specific for Down syndrome children may be used in optimizing direct Egyptian DS children care and in providing anticipatory guidance in term of optimal physical growth and early detection of hidden factors affecting growth. © 2012 Wiley Periodicals, Inc.