How to Cite this Article: Bamshad MJ, Shendure JA, Valle D, Hamosh A, Lupski JR, Gibbs RA, Boerwinkle E, Lifton RP, Gerstein M, Gunel M, Mane S, Nickerson DA on behalf of the Centers for Mendelian Genomics. 2012. The Centers for Mendelian Genomics: A new large-scale initiative to identify the genes underlying rare Mendelian conditions. Am J Med Genet Part A. 158A:1523–1525.
The Centers for Mendelian Genomics: A new large-scale initiative to identify the genes underlying rare Mendelian conditions†
Article first published online: 24 MAY 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Volume 158A, Issue 7, pages 1523–1525, July 2012
How to Cite
Bamshad, M. J., Shendure, J. A., Valle, D., Hamosh, A., Lupski, J. R., Gibbs, R. A., Boerwinkle, E., Lifton, R. P., Gerstein, M., Gunel, M., Mane, S., Nickerson, D. A. and on behalf of the Centers for Mendelian Genomics (2012), The Centers for Mendelian Genomics: A new large-scale initiative to identify the genes underlying rare Mendelian conditions. Am. J. Med. Genet., 158A: 1523–1525. doi: 10.1002/ajmg.a.35470
- Issue published online: 18 JUN 2012
- Article first published online: 24 MAY 2012
- Manuscript Accepted: 19 APR 2012
- Manuscript Received: 2 APR 2012
- Yale Center for Mendelian Genomics. Grant Number: HG006504
- Baylor-Hopkins Center for Mendelian Genomics. Grant Number: HG006542
- University of Washington Center for Mendelian Genomcis. Grant Number: HG006493
- exome sequencing;
Next generation exome sequencing (ES) and whole genome sequencing (WGS) are new powerful tools for discovering the gene(s) that underlie Mendelian disorders. To accelerate these discoveries, the National Institutes of Health has established three Centers for Mendelian Genomics (CMGs): the Center for Mendelian Genomics at the University of Washington; the Center for Mendelian Genomics at Yale University; and the Baylor–Johns Hopkins Center for Mendelian Genomics at Baylor College of Medicine and Johns Hopkins University. The CMGs will provide ES/WGS and extensive analysis expertise at no cost to collaborating investigators where the causal gene(s) for a Mendelian phenotype has yet to be uncovered. Over the next few years and in collaboration with the global human genetics community, the CMGs hope to facilitate the identification of the genes underlying a very large fraction of all Mendelian disorders; see http://mendelian.org. © 2012 Wiley Periodicals, Inc.