Get access

The Centers for Mendelian Genomics: A new large-scale initiative to identify the genes underlying rare Mendelian conditions

Authors

  • Michael J. Bamshad,

    Corresponding author
    1. Department of Pediatrics, University of Washington, Seattle, Washington
    2. Department of Genome Sciences, University of Washington, Seattle, Washington
    3. Seattle Children's Hospital, Seattle, Washington
    • Division of Genetic Medicine, Department of Pediatrics, University of Washington School of Medicine, 1959 NE Pacific Street, HSB RR349, Box 356320, Seattle, WA 98195.
    Search for more papers by this author
  • Jay A. Shendure,

    1. Department of Genome Sciences, University of Washington, Seattle, Washington
    Search for more papers by this author
  • David Valle,

    1. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Search for more papers by this author
  • Ada Hamosh,

    1. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Search for more papers by this author
  • James R. Lupski,

    1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas
    2. Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    3. Texas Children's Hospital, Houston, Texas
    4. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas
    Search for more papers by this author
  • Richard A. Gibbs,

    1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas
    2. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas
    Search for more papers by this author
  • Eric Boerwinkle,

    1. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas
    2. Human Genetics Center, University of Texas Health Sciences Center at Houston, Houston, Texas
    Search for more papers by this author
  • Richard P. Lifton,

    1. Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
    Search for more papers by this author
  • Mark Gerstein,

    1. Department of Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut
    Search for more papers by this author
  • Murat Gunel,

    1. Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
    2. Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut
    Search for more papers by this author
  • Shrikant Mane,

    1. Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
    Search for more papers by this author
  • Deborah A. Nickerson,

    1. Department of Genome Sciences, University of Washington, Seattle, Washington
    Search for more papers by this author
  • on behalf of the Centers for Mendelian Genomics


  • How to Cite this Article: Bamshad MJ, Shendure JA, Valle D, Hamosh A, Lupski JR, Gibbs RA, Boerwinkle E, Lifton RP, Gerstein M, Gunel M, Mane S, Nickerson DA on behalf of the Centers for Mendelian Genomics. 2012. The Centers for Mendelian Genomics: A new large-scale initiative to identify the genes underlying rare Mendelian conditions. Am J Med Genet Part A. 158A:1523–1525.

Abstract

Next generation exome sequencing (ES) and whole genome sequencing (WGS) are new powerful tools for discovering the gene(s) that underlie Mendelian disorders. To accelerate these discoveries, the National Institutes of Health has established three Centers for Mendelian Genomics (CMGs): the Center for Mendelian Genomics at the University of Washington; the Center for Mendelian Genomics at Yale University; and the Baylor–Johns Hopkins Center for Mendelian Genomics at Baylor College of Medicine and Johns Hopkins University. The CMGs will provide ES/WGS and extensive analysis expertise at no cost to collaborating investigators where the causal gene(s) for a Mendelian phenotype has yet to be uncovered. Over the next few years and in collaboration with the global human genetics community, the CMGs hope to facilitate the identification of the genes underlying a very large fraction of all Mendelian disorders; see http://mendelian.org. © 2012 Wiley Periodicals, Inc.

Get access to the full text of this article

Ancillary