How to Cite this Article: Shimojima K, Okumura A, Mori H, Abe S, Ikeno M, Shimizu T, Yamamoto T. 2012. De novo microdeletion of 5q14.3 excluding MEF2C in a patient with infantile Spasms, microcephaly, and agenesis of the corpus callosum. Am J Med Genet Part A. 158A:2272–2276.
De novo microdeletion of 5q14.3 excluding MEF2C in a patient with infantile spasms, microcephaly, and agenesis of the corpus callosum†
Article first published online: 27 JUL 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Volume 158A, Issue 9, pages 2272–2276, September 2012
How to Cite
Shimojima, K., Okumura, A., Mori, H., Abe, S., Ikeno, M., Shimizu, T. and Yamamoto, T. (2012), De novo microdeletion of 5q14.3 excluding MEF2C in a patient with infantile spasms, microcephaly, and agenesis of the corpus callosum. Am. J. Med. Genet., 158A: 2272–2276. doi: 10.1002/ajmg.a.35490
- Issue published online: 24 AUG 2012
- Article first published online: 27 JUL 2012
- Manuscript Accepted: 25 APR 2012
- Manuscript Received: 14 NOV 2011
- Japan Ministry of Education, Science, Sports and Culture. Grant Numbers: 21591334, 22890199
- 5q14.3 deletion;
- infantile spasms;
- agenesis of the corpus callosum
The 5q14.3 microdeletion syndrome has recently been recognized as a clinical entity manifesting as severe intellectual disability, epilepsy, and brain malformations. Analysis of the shortest region of overlap among patients with this syndrome and subsequent identification of nucleotide alterations in the coding region of myocyte enhancer factor 2C gene (MEF2C) have suggested MEF2C as the gene responsible for the 5q14.3 microdeletion syndrome. We identified a de novo 3.4-Mb deletion of 5q14.3 in a patient with infantile spasms, microcephaly, and brain malformation. The deleted region in the present patient was positional toward the centromere, and MEF2C was not included in the deleted region. However the neurological and dysmorphic features of the present patient resembled those of patients with the 5q14.3 microdeletion syndrome. We consider that a positional effect is the likely explanation for this evidence. To study the precise mechanism of this positional effect, further information is required on patients showing atypical deletions neighboring MEF2C. © 2012 Wiley Periodicals, Inc.