How to Cite this Article: Hall JG. 2012. Arthrogryposis (multiple congenital contractures) associated with failed termination of pregnancy. Am J Med Genet Part A. 158A:2214–2220.
Version of Record online: 7 AUG 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Volume 158A, Issue 9, pages 2214–2220, September 2012
How to Cite
Hall, J. G. (2012), Arthrogryposis (multiple congenital contractures) associated with failed termination of pregnancy. Am. J. Med. Genet., 158A: 2214–2220. doi: 10.1002/ajmg.a.35531
Conflicts of interest: nothing to declare.
- Issue online: 24 AUG 2012
- Version of Record online: 7 AUG 2012
- Manuscript Accepted: 21 MAY 2012
- Manuscript Received: 27 MAR 2012
- failed termination of pregnancy;
- multiple congenital contractures;
- attempted termination of pregnancy;
- intellectual disability;
The purpose of this study was to establish whether an increase in failed termination of pregnancy is observed among individuals with arthrogryposis (multiple congenital contractures). A total of 2,500 unselected patients with arthrogryposis collected by the author over a 35-year period were reviewed. The cases included referrals, consultations, personal examinations, and correspondence. They were reviewed for clinical features, pregnancy complications, family history, and a history of attempted terminations of the pregnancy. Eleven cases of failed terminations of pregnancy in which the individuals were subsequently born with arthrogryposis were identified. We conclude that infants who survive attempted termination of pregnancy (both surgical and medical) may be at an increased risk to be born with multiple congenital contractures. Careful examination of the tissue and a post-procedure ultrasound will help to assure that the termination has been successful. Those infants surviving attempted termination of pregnancy who have arthrogryposis are also at >50% risk for intellectual disability. © 2012 Wiley Periodicals, Inc.