The authors have no conflict of interest to declare.
Article first published online: 13 DEC 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Volume 161, Issue 1, pages 70–75, January 2013
How to Cite
Nabukera, S. K., Romitti, P. A., Caspers, K. M., Street, N., Cunniff, C., Mathews, K. D., Fox, D. J., Puzhankara, S., Ciafaloni, E., James, K. A., Su, Y. and the MD STARnet (2013), Reproductive patterns among mothers of males diagnosed with Duchenne or Becker muscular dystrophy. Am. J. Med. Genet., 161: 70–75. doi: 10.1002/ajmg.a.35682
Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
How to Cite this Article: Nabukera SK, Romitti PA, Caspers KM, Street N, Cunniff C, Mathews KD, Fox DJ, Puzhankara S, Ciafaloni E, James KA, Su Y, the MD STARnet. 2012. Reproductive patterns among mothers of males diagnosed with Duchenne or Becker muscular dystrophy. Am J Med Genet Part A 161A:70–75.
- Issue published online: 22 DEC 2012
- Article first published online: 13 DEC 2012
- Manuscript Accepted: 24 AUG 2012
- Manuscript Received: 25 MAY 2012
- Centers for Disease Control and Prevention. Grant Numbers: U01DD000189, U01DD000831
- Becker muscular dystrophy;
- Duchenne muscular dystrophy;
- live birth;
Diagnosis of a child with Duchenne or Becker muscular dystrophy (DBMD) may impact future maternal reproductive choice; however, little is known about the reproductive patterns of mothers with a male child diagnosed with DBMD. Using population-based surveillance data collected by the muscular dystrophy surveillance, tracking, and research network, the proportion of mothers who conceived and delivered a live birth following the diagnosis of DBMD in an affected male child and factors associated with such reproductive choice were identified. To accomplish this, maternal demographic data were linked to birth certificate data to construct the reproductive history for 239 mothers. Univariable and bivariable analyses were conducted to determine the proportion of mothers delivering a live birth and associated factors. By the time of the current study, 96 (40.2%) of the 239 mothers had at least one live birth following delivery of their oldest affected male child; 53 (22.2%) of these mothers had a live birth before and 43 (18.0%) had a live birth after DBMD diagnosis of a male child. Mothers with a live birth after diagnosis were significantly younger at diagnosis of the oldest affected male child (26.2 ± 4.2 years vs. 31.5 ± 5.5 years), and were less likely to be white non-Hispanic compared to those with no live birth after diagnosis. These results suggest that about one in five mothers deliver a live birth subsequent to DBMD diagnosis in a male child. Maternal age and race/ethnicity were associated with this reproductive choice. © 2012 Wiley Periodicals, Inc.