Artery tortuosity syndrome exhibiting early-onset emphysema with novel compound heterozygous SLC2A10 mutations

Authors

  • Yoshiko Takahashi,

    Corresponding author
    1. Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan
    • Department of Pediatrics, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan.
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  • Katsunori Fujii,

    1. Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan
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  • Akiko Yoshida,

    1. Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
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  • Hiroko Morisaki,

    1. Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
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  • Yoichi Kohno,

    1. Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan
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  • Takayuki Morisaki

    1. Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    2. Department of Molecular Pathophysiology, Osaka University Graduate School of Pharmaceutical Sciences, Osaka, Japan
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  • How to Cite this Article: Takahashi Y, Fujii K, Yoshida A, Morisaki H, Kohno Y, Morisaki T. 2013. Artery tortuosity syndrome exhibiting early-onset emphysema with novel compound heterozygous SLC2A10 mutations. Am J Med Genet Part A 161A:856–859

Abstract

We report on a 2-year-old Japanese boy with early-onset pulmonary emphysema, exhibiting dysmorphic face, loose skin, and inguinal and Morgagni hernias. He was admitted to our hospital owing to refractory respiratory infection. On the basis of his clinical features, we investigated the SLC2A10 gene and identified novel compound heterozygous mutations of c.417T > A and c.692G > A, leading to the diagnosis of artery tortuosity syndrome (ATS). This syndrome is an extremely rare autosomal recessive disorder characterized by tortuosity and elongation of the large and medium-sized arteries, hyperextensible skin, and diverse hernias, mostly reported from Europe and Middle Eastern countries, but not from Asia. Although chronic obstructive pulmonary disease, namely, emphysema, has not been well documented in ATS, it may be likely because TGF-beta up-regulation is known to be evoked by SLC2A10 mutations, resulting in reconstruction of pulmonary endothelial cells and emphysema. This is the first report of ATS associated with early-onset pulmonary emphysema, suggesting that patients with ATS may also require close attention for chronic obstructive pulmonary disease. © 2013 Wiley Periodicals, Inc.

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