Conflict of interest: None.
Corpus Callosum Shape Is Altered in Individuals With Nonsyndromic Cleft Lip and Palate
Article first published online: 26 MAR 2013
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Volume 161, Issue 5, pages 1002–1007, May 2013
How to Cite
2012. Corpus callosum shape is altered in individuals with nonsyndromic cleft lip and palate. Am J Med Genet Part A 161A:1002–1007., , , , , .
- Issue published online: 22 APR 2013
- Article first published online: 26 MAR 2013
- Manuscript Accepted: 6 DEC 2012
- Manuscript Received: 28 AUG 2012
- Basil O'Connor Award from the March of Dimes: #5-FY98–0541
- nonsyndromic clefting;
- corpus callosum;
- geometric morphometrics
Individuals with nonsyndromic cleft lip with or without cleft palate (CL/P) have altered brain structure compared with healthy controls. Preliminary evidence suggests that the corpus callosum may be dysmorphic in orofacial clefting; however, this midline brain structure has not been systematically assessed in this population. The goal of the present study was to carry out a morphometric assessment of the corpus callosum and its relationship to cognitive performance in a well-characterized patient cohort with orofacial cleft. Midline brain images were obtained from previously collected MRI scans of 24 CL/P subjects and 40-adult-male controls. Eight landmarks on the corpus callosum were digitized on each image and their x,y coordinate locations saved. A geometric morphometrics analysis was applied to the landmark coordinate data to test for shape differences across groups. The relationship between corpus callosum shape and IQ was explored with nonparametric correlation coefficients. Results revealed significant differences in mean corpus callosum shape between CL/P cases and controls (P = 0.029). The CL/P corpus callosum was characterized by increased overall convexity resulting from a superior and posterior displacement. Within CL/P cases, increased corpus callosum shape dysmorphology was moderately correlated with reduced performance IQ (r = 0.546). These results provide additional evidence that midline brain changes may be an important part of the orofacial cleft phenotype. © 2013 Wiley Periodicals, Inc.