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A boy with Burkitt lymphoma associated with Noonan syndrome due to a mutation in RAF1

Authors


  • Conflicts of interest: none to declare.
  • Paola Cianci and Valentina Tono equally contributed to this study.

Correspondence to:

Dr. Angelo Selicorni,

Pediatric Genetic Unit, Pediatric Department of MBBM Foundation, S.Gerardo Hospital, Monza, Italy. E-mail: angelo.selicorni@gmail.com

Abstract

This article reports on an association between Burkitt lymphoma and Noonan syndrome (NS) due to a RAF1 gene mutation. The patient was a 7-year-old boy with NS, who was included in the first series reporting the association between Noonan and RAF1, and who later presented with a 2-week history of asymptomatic unilateral tonsillar swelling and ipsilateral cervical lymphadenopathy. Histological and biological examinations of the tonsillar biopsy led to the diagnosis of Burkitt lymphoma. While there is a well-established association between NS and solid cell tumors, this is the first case described in the literature of Burkitt lymphoma in a patient with NS, and adds to the growing list of data supporting neoplasia's association with NS. © 2013 Wiley Periodicals, Inc.

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