Conflicts of interest: none.
Attitudes of African Americans Toward Return of Results From Exome and Whole Genome Sequencing
Article first published online: 22 APR 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Volume 161, Issue 5, pages 1064–1072, May 2013
How to Cite
2013. Attitudes of African Americans toward return of results from exome and whole genome sequencing. Am J Med Genet Part A 161A:1064–1072., , , , .
- Issue published online: 22 APR 2013
- Article first published online: 22 APR 2013
- Manuscript Accepted: 4 FEB 2013
- Manuscript Received: 14 DEC 2012
- National Institutes of Health/National Human Genome Research Institute. Grant Numbers: 1U54HG006493, 1RC2HG005608, 5ROOHG004316, 5RO1HG006618
- Life Sciences Discovery Fund. Grant Numbers: 2065508, 0905001
- Washington Research Foundation
- exome sequencing;
- whole genome sequencing;
- African Americans;
- return of results
Exome sequencing and whole genome sequencing (ES/WGS) present patients and research participants with the opportunity to benefit from a broad scope of genetic results of clinical and personal utility. Yet, this potential for benefit also risks disenfranchising populations such as African Americans (AAs) that are already underrepresented in genetic research and utilize genetic tests at lower rates than other populations. Understanding a diverse range of perspectives on consenting for ES/WGS and receiving ES/WGS results is necessary to ensure parity in genomic health care and research. We conducted a series of 13 focus groups (n = 76) to investigate if and how attitudes toward participation in ES/WGS research and return of results from ES/WGS differ between self-described AAs and non-AAs. The majority of both AAs and non-AAs were willing to participate in WGS studies and receive individual genetic results, but the fraction not interested in either was higher in AAs. This is due in part to different expectations of health benefits from ES/WGS and how results should be managed. Our results underscore the need to develop and test culturally tailored strategies for returning ES/WGS results to AAs. © 2013 Wiley Periodicals, Inc.