Giulia Prunotto and Paola Cianci equally contributed to this study.
Two cases of hepatic adenomas in patients with wolf-hirschhorn syndrome: A new rare complication?
Article first published online: 21 MAY 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A
Volume 161, Issue 7, pages 1759–1762, July 2013
How to Cite
2013. Two cases of hepatic adenomas in patients with Wolf–Hirschhorn syndrome: A new rare complication? Am J Med Genet Part A 161A:1759–1762., , , , , , , .
Conflict of interest: none.
- Issue published online: 19 JUN 2013
- Article first published online: 21 MAY 2013
- Manuscript Accepted: 10 MAR 2013
- Manuscript Received: 15 JAN 2013
- Wolf–Hirschhorn syndrome;
- hepatic adenoma
Wolf–Hirschhorn syndrome (WHS) is a rare microdeletion syndrome associated with a characteristic facial appearance, failure to thrive, psychomotor delays, and various major malformations of internal organs; many medical complications have been described (feeding difficulties, epilepsy, hearing problems). Benign or malignant oncologic problems are not a typical feature of the natural history of these patients. We report on two patients with WHS patients in whom hepatic adenoma (HA) were diagnosed during adolescence. The clinical evolution of liver involvement was different between the two. We discuss the possibility of considering HA as a rare medical problem in the follow-up of WHS patients. © 2013 Wiley Periodicals, Inc.