• Aoki Y, Niihori T, Kawame H, Kurosawa K, Ohashi H, Tanaka Y, Filocamo M, Kato K, Suzuki Y, Kure S, Matsubara Y. 2005. Germline mutations in HRAS proto-oncogene cause Costello syndrome. Nat Genet 37:10381040.
  • Armour CM, Allanson JE. Further delineation of cardio-facio-cutaneous syndrome: Clinical features of 38 individuals with proven mutations. J Med Genet 2008. 45:249254.
  • Gripp KW, Lin AE. 2012a. Costello syndrome: A Ras/mitogen activated protein kinase pathway syndrome (rasopathy) resulting from HRAS germline mutations. Genet Med 14:285292.
  • Gripp KW, Lin AE. (updated Jan. 2012b). Costello syndrome in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle. 2006–2012. Available at Accessed March 15, 2012.
  • Harris NH. 1976. Acetabular growth potential in congenital dislocation of the hip and some factors upon which it may depend. Clin Orthop Relat Res 119:99106.
  • Hopkins E, Lin A, Krepkovich K, Axelrad ME, Sol-Church K, Stabley D, Hossain J, Gripp KW. 2009. Living with Costello syndrome: Quality of life issues in older individuals. Am J Med Genet Part A 152A:8490.
  • Reimers J. 1980. The stability of the hip in children. A radiological study of the results of muscle surgery in cerebral palsy. Acta Orthop Scand Suppl 184:1100.
  • Reinker KA, Stevenson DA, Tsung A. Orthopaedic conditions in Ras/MAPK related disorders. J Pediatr Orthop 2011. 31(5):599605.
  • Scrutton D, Baird G. 1997. Surveillance measures of the hips of children with bilateral cerebral palsy. Arch Dis Childhood 76:381384.
  • Shukry M, Boucher J, Madduri D, De Armendi A. 2008. Anesthetic considerations in the child with Costello syndrome: Risk of cardiac arrest upon induction of anesthesia. Pediatr Anesth 18:567568.
  • Stevenson DA, Yang F-C. 2011. The musculoskeletal phenotype of the RASopathies. Am J Med Genet Part C 157C:90103.
  • Tidyman W, Lee HS, Rauen KA. 2011. Skeletal muscle pathology in Costello and Cardio-Facio Cutaneous syndromes: Developmental consequences of germline Ras/MAPK activation on myogenesis. Am J Med Genet Part C 157C:104114.
  • Van der Burgt I, Kupsky W, Stassou S, Nadroo A, Barroso C, Diem A, Kratz CP, Dvorsky R, Ahmadian MR, Zenker M. 2007. Myopathy caused by HRAS germline mutations: Implications for disturbed myogenic differentiation in the presence of constitutive HRAS activation. J Med Genet 44:459462.
  • White S, Graham J, Kerr B, Gripp KW, Weksberg R, Cytrynbaum C, Reeder J, Stewart F, Edwards M, Wilson M, Bankier A. 2005. The adult phenotype in Costello syndrome. Am J Med Genet A 136A:128135.
  • Yassir W, Grottkau B, Goldberg M. 2003. Costello syndrome: Orthopaedic manifestations and functional health. J Pediatr Orthop 23:9.