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Apolipoprotein E in schizophrenia: A French association study and meta-analysis

Authors

  • Franck Schürhoff,

    Corresponding author
    1. Service de Psychiatrie Adulte, Hôpital Albert Chenevier et Henri Mondor (Assistance Publique-Hôpitaux de Paris) Créteil, France
    2. Unité INSERM U 513, “Neurobiologie et Psychiatrie,” Hôpital Henri Mondor, Créteil, France
    • Service de Psychiatrie Adulte du Pr. Rouillon, Hôpital Albert Chenevier, 40 rue Mesly, 94 000 Créteil, France.
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  • Marie-Odile Krebs,

    1. EMI 0117 INSERM, Centre Paul Broca, 2ter rue d'Alesia, Hôpital St-Anne, Paris, France
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  • Andrei Szöke,

    1. Service de Psychiatrie Adulte, Hôpital Albert Chenevier et Henri Mondor (Assistance Publique-Hôpitaux de Paris) Créteil, France
    2. Unité INSERM U 513, “Neurobiologie et Psychiatrie,” Hôpital Henri Mondor, Créteil, France
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  • Jean-Yves Loze,

    1. Service de Psychiatrie Adulte, Hôpital Albert Chenevier et Henri Mondor (Assistance Publique-Hôpitaux de Paris) Créteil, France
    2. Unité INSERM U 513, “Neurobiologie et Psychiatrie,” Hôpital Henri Mondor, Créteil, France
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  • Céline Goldberger,

    1. EMI 0117 INSERM, Centre Paul Broca, 2ter rue d'Alesia, Hôpital St-Anne, Paris, France
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  • Valérie Quignon,

    1. Service de Biochimie et Biologie Moléculaire, CR. C Bernard, Hôpital Lariboisiere, Paris, France
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  • Jean Tignol,

    1. Service de Psychiatrie Adulte, Hôpital Charles Perrens, Bordeaux, France
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  • Frédéric Rouillon,

    1. Service de Psychiatrie Adulte, Hôpital Albert Chenevier et Henri Mondor (Assistance Publique-Hôpitaux de Paris) Créteil, France
    2. Unité INSERM U 513, “Neurobiologie et Psychiatrie,” Hôpital Henri Mondor, Créteil, France
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  • Jean-Louis Laplanche,

    1. Service de Biochimie et Biologie Moléculaire, CR. C Bernard, Hôpital Lariboisiere, Paris, France
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  • Marion Leboyer

    1. Service de Psychiatrie Adulte, Hôpital Albert Chenevier et Henri Mondor (Assistance Publique-Hôpitaux de Paris) Créteil, France
    2. Unité INSERM U 513, “Neurobiologie et Psychiatrie,” Hôpital Henri Mondor, Créteil, France
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Abstract

Schizophrenic disorders are complex genetic disorders that may involve multiple genes of small effect. Apolipoprotein E (ApoE) gene variants are associated with alterations in brain function and an increased risk of Alzheimer's disease (AD). However, conflicting results have been reported in schizophrenia. We compared the ApoE genotypes of 114 French Caucasian schizophrenic patients and 91 normal controls. No differences in ApoE allele or genotype frequencies were observed between the two groups. However, we observed a possible association between male schizophrenic patients and the ApoE ε2ε3 genotype. In addition, a meta-analysis of all published case-control studies on ApoE and schizophrenia did not support a major role for ApoE gene variants in schizophrenia as a whole. However, ApoE may be associated with particular forms of schizophrenia. © 2003 Wiley-Liss, Inc.

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