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Invited Paper
Nature and nurture: Interaction and coaction
Article first published online: 19 JUN 2003
DOI: 10.1002/ajmg.b.20044
Copyright © 2004 Wiley-Liss, Inc.
Issue
1552-485X/asset/cover.gif?v=1&s=1311dc9f78d73ed3cc2334be9fec1778ee8bc608 "American Journal of Medical Genetics Part B: Neuropsychiatric Genetics")
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 124B, Issue 1, pages 124–130, 1 January 2004
Additional Information
How to Cite
McClearn, G. E. (2004), Nature and nurture: Interaction and coaction. Am. J. Med. Genet., 124B: 124–130. doi: 10.1002/ajmg.b.20044
Publication History
- Issue published online: 12 DEC 2003
- Article first published online: 19 JUN 2003
- Manuscript Accepted: 20 MAR 2003
- Manuscript Received: 5 MAR 2002
- Abstract
- Article
- References
- Cited By
Keywords:
- nature;
- nurture;
- epistasis
Abstract
The sophistry of the “Nature versus Nurture” formulation is becoming ever more apparent as a consequence of the rapid advances in understanding of the basic mechanisms of heredity and in the application of this knowledge to a wide spectrum of issues of human health and welfare. It is clear that a more accurate formulation would emphasize the interaction and coaction of genetic and environmental factors in their influence on complex phenotypes. Furthermore, the potential dependence of the influence of a particular gene on other genes in the system is increasingly realized. This paper documents these perspectives by examples of gene-environment interaction and gene-gene interaction both from animal model and from human research that reveal both the potential power and subtlety of these interactive effects. © 2004 Wiley-Liss, Inc.