Nature and nurture: Interaction and coaction
Version of Record online: 19 JUN 2003
Copyright © 2004 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 124B, Issue 1, pages 124–130, 1 January 2004
How to Cite
McClearn, G. E. (2004), Nature and nurture: Interaction and coaction. Am. J. Med. Genet., 124B: 124–130. doi: 10.1002/ajmg.b.20044
- Issue online: 12 DEC 2003
- Version of Record online: 19 JUN 2003
- Manuscript Accepted: 20 MAR 2003
- Manuscript Received: 5 MAR 2002
The sophistry of the “Nature versus Nurture” formulation is becoming ever more apparent as a consequence of the rapid advances in understanding of the basic mechanisms of heredity and in the application of this knowledge to a wide spectrum of issues of human health and welfare. It is clear that a more accurate formulation would emphasize the interaction and coaction of genetic and environmental factors in their influence on complex phenotypes. Furthermore, the potential dependence of the influence of a particular gene on other genes in the system is increasingly realized. This paper documents these perspectives by examples of gene-environment interaction and gene-gene interaction both from animal model and from human research that reveal both the potential power and subtlety of these interactive effects. © 2004 Wiley-Liss, Inc.