Interleukin-1β (IL-1β) gene and increased risk for the depressive symptom-dimension in schizophrenia spectrum disorders
Version of Record online: 20 AUG 2003
Copyright © 2003 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 124B, Issue 1, pages 10–14, 1 January 2004
How to Cite
Rosa, A., Peralta, V., Papiol, S., Cuesta, M. J., Serrano, F., Martínez-Larrea, A. and Fañanás, L. (2004), Interleukin-1β (IL-1β) gene and increased risk for the depressive symptom-dimension in schizophrenia spectrum disorders. Am. J. Med. Genet., 124B: 10–14. doi: 10.1002/ajmg.b.20074
- Issue online: 12 DEC 2003
- Version of Record online: 20 AUG 2003
- Manuscript Accepted: 21 MAY 2003
- Manuscript Received: 3 SEP 2002
- Theodore and Vada Stanley Foundation
- University of Barcelona (to A.R.)
- depressive symptom-dimension;
- family-based association study;
Interleukin-1β (IL-1β), as well as other cytokines, has been classically implicated in the pathophysiology of major psychiatric disorders such as schizophrenia and major depression, and recent studies have implicated the IL-1β gene and schizophrenia. Nevertheless, new approaches to this complex phenotype are necessary to clarify the risk conferred by this gene, either to the disorder or to its clinical manifestations. The aim of the present study was to explore the effect of a genetic polymorphism of the promoter region of the IL-1β gene, in schizophrenia defined with: (i) a categorical diagnosis and (ii) a multidimensional symptom approach. We studied 356 individuals from 89 nuclear families consisting of one affected individual and the unaffected father, mother, and sib, in a family-based association study design. We find a trend for biased transmission of allele 2 from heterozygous parents to affected offspring, categorically defined (P = 0.07). This tendency was not observed in the healthy offspring. Using a multidimensional symptom approach to the diagnosis, the association was confirmed in psychotic patients showing the depressive symptom-dimension (P = 0.02). © 2003 Wiley-Liss, Inc.