Confirming RGS4 as a susceptibility gene for schizophrenia
Article first published online: 5 SEP 2003
Copyright © 2003 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 125B, Issue 1, pages 50–53, 15 February 2004
How to Cite
Morris, D. W., Rodgers, A., McGhee, K. A., Schwaiger, S., Scully, P., Quinn, J., Meagher, D., Waddington, J. L., Gill, M. and Corvin, A. P. (2004), Confirming RGS4 as a susceptibility gene for schizophrenia. Am. J. Med. Genet., 125B: 50–53. doi: 10.1002/ajmg.b.20109
- Issue published online: 27 JAN 2004
- Article first published online: 5 SEP 2003
- Manuscript Accepted: 26 JUN 2003
- Manuscript Received: 22 APR 2003
- linkage disequilibrium
A recent study identified a putative association between variants in the regulator of G-protein signalling 4 (RGS4) and schizophrenia, Chowdari et al. [2002: Hum Mol Genet 11: 1373–1380]. RGS4 is both a positional and functional candidate gene for schizophrenia. Chowdari and colleagues identified association at this locus in a number of distinct and ethnically diverse samples, although the pattern of association was not the same in all the samples. Our study attempted to replicate this association in an independent Irish sample of schizophrenia cases and controls. We succeeded in detecting evidence of association at the RGS4 locus. The signal comes from a four-marker haplotype that is in significant excess in our case sample. The same haplotype is in excess in the Caucasian schizophrenia sample used by Chowdari et al. [2002: Hum Mol Genet 11: 1373–1380]. This study provides further support for the contribution of RGS4 to schizophrenia susceptibility. © 2003 Wiley-Liss, Inc.