Several lines of evidence suggest an involvement of the noradrenergic neurotransmitter system in the pathogenesis of bipolar affective disorder (BPAD). Three genes for α-adrenergic receptors (ADRA) are located in chromosomal regions that showed evidence for linkage: The α1c-adrenergic (ADRA-1C) receptor gene on 8p21, the α2a-adrenergic (ADRA-2A) receptor gene on 10q25, and the α2c-adrenergic (ADRA-2C) receptor on 4p16. In a BPAD sample of 120 parent-offspring triads, we genotyped a 492 Cys/Arg variant in exon 2 of the ADRA-1C gene, a -1291 G/C variant in the 5′UTR of the ADRA-2A gene, and a STR marker (adra2c1) in the 5′UTR of the ADRA-2C gene. Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes. © 2003 Wiley-Liss, Inc.