Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
Article first published online: 22 MAR 2004
Copyright © 2004 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 128B, Issue 1, pages 19–20, 1 July 2004
How to Cite
Zammit, S., Jones, G., Jones, S. J., Norton, N., Sanders, R. D., Milham, C., McCarthy, G. M., Jones, L. A., Cardno, A. G., Gray, M., Murphy, K. C., O'Donovan, M. C. and Owen, M. J. (2004), Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. Am. J. Med. Genet., 128B: 19–20. doi: 10.1002/ajmg.b.30021
- Issue published online: 16 JUN 2004
- Article first published online: 22 MAR 2004
- Manuscript Accepted: 12 JAN 2004
- Manuscript Received: 11 JUN 2003
- MRC Programme Grant
- MRC Training Fellowship
Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior. © 2004 Wiley-Liss, Inc.