Mei Shuang and Jing Liu contributed equally to this study.
Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios†
Article first published online: 18 AUG 2004
Copyright © 2004 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 131B, Issue 1, pages 48–50, 15 November 2004
How to Cite
Shuang, M., Liu, J., Jia, M. X., Yang, J. Z., Wu, S. P., Gong, X. H., Ling, Y. S., Ruan, Y., Yang, X. L. and Zhang, D. (2004), Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios. Am. J. Med. Genet., 131B: 48–50. doi: 10.1002/ajmg.b.30025
- Issue published online: 25 OCT 2004
- Article first published online: 18 AUG 2004
- Manuscript Accepted: 3 DEC 2003
- Manuscript Received: 11 AUG 2003
- National Natural Scientific Foundation of China. Grant Number: 30270495
- National Key Project. Grant Number: 2002BA711A07-06
- Beijing Biomedical R & D Innovation Program. Grant Number: H010210180112
- association study;
- glutamate receptor 6;
- single nucleotide polymorphism
The glutamate pathways are involved in diverse processes such as learning and memory, epilepsy, and they play important roles in neural plasticity, neural development, and neurodegeneration. It has been proposed that autism could be a hypoglutamatergic disorder. Recently, Jamain et al. [Mol Psychiatry 7:302–310] reported that the glutamate receptor 6 (GluR6 or GRIK2) is in linkage disequilibrium with autism. In the present study, the transmission disequilibrium test (TDT) and the haplotype transmission were performed to analyze the four SNPs (SNP1: rs995640; SNP2: rs2227281; SNP3: rs2227283; SNP4: rs2235076) of GluR6 in 174 Chinese Han parent-offspring trios. The TDT demonstrated that the two SNPs (SNP2 and SNP3) showed preferential transmission (TDT P = 0.032). The global χ2 test for haplotype transmission also revealed an association between GluR6 and autism (χ2 = 10.78, df = 3, P = 0.013). Our results suggested that GluR6 is in linkage disequilibrium with autism. © 2004 Wiley-Liss, Inc.