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Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment†
Article first published online: 3 DEC 2004
Copyright © 2004 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 132B, Issue 1, pages 126–130, 5 January 2005
How to Cite
Gervai, J., Nemoda, Z., Lakatos, K., Ronai, Z., Toth, I., Ney, K. and Sasvari-Szekely, M. (2005), Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment. Am. J. Med. Genet., 132B: 126–130. doi: 10.1002/ajmg.b.30102
- Issue published online: 22 DEC 2004
- Article first published online: 3 DEC 2004
- Manuscript Accepted: 15 JUN 2004
- Manuscript Received: 22 AUG 2003
- OTKA (to JG). Grant Number: T-038407
- OMFB (to MS-S). Grant Number: 212/2002
- NKFP (to MS-S and GJ). Grant Number: 1A/0008/2002
- OTKA (to KL). Grant Number: D-045940
- genetics of attachment;
- DRD4 exon III 48 basepair repeat polymorphism;
- DRD4 −521 C/T promoter polymorphism;
- haplotype analysis;
- attention deficit/hyperactivity disorder
Following up the results of a previous population association study (Lakatos et al. [2000: Mol Psychiatry 5:633–637; Lakatos et al. [2002: Mol Psychiatry 7:27–31]) by analyses based on parental genetic data confirmed the link between infant attachment and the dopamine D4 receptor (DRD4) gene. Extended transmission disequilibrium tests (ETDT) were performed to determine whether biased transmission of exon III 48 basepair repeat alleles occurred to infants displaying disorganized and secure attachment behavior with their mothers. The overall allele-wise TDTs were significant for both groups (P = 0.038 and 0.020, respectively): a trend for preferential transmission of the seven-repeat allele to disorganized infants was observed (TDT = 3.27, df = 1, P = 0.071), and there was a significant non-transmission of the same allele to securely attached infants (TDT = 6.00, df = 1, P = 0.014). Analysis of haplotypes of the exon III repeat and the −521 C/T promoter polymorphisms in family trios showed that the transmission bias in the larger secure group was due to the low-rate transmission of the T.7 haplotype containing both the seven-repeat and the −521 T alleles (TDT = 4.46, df = 1, P = 0.035). This suggests that not carrying the T.7 haplotype of the DRD4 gene may act as a resilience factor in the optimal development of early attachment. © 2004 Wiley-Liss, Inc.