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Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence

Authors

  • Richard Feinn,

    1. Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut
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  • Maggie Nellissery,

    1. Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut
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  • Henry R. Kranzler

    Corresponding author
    1. Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut
    • Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-2103.
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Abstract

The neurotransmitter serotonin (5-HT) has been shown to regulate alcohol consumption in both animals and humans. Since activity of the 5-HT transporter protein (5-HTT) regulates 5-HT levels, the gene encoding this protein may contribute to the risk of alcohol dependence (AD). Studies of the association to AD of a functional insertion-deletion polymorphism in the 5-HTT-linked promoter region (5-HTTLPR) have yielded inconsistent results. We conducted a meta-analysis of data from 17 published studies (including 3,489 alcoholics and 2,325 controls) investigating the association between 5-HTTLPR alleles and AD. The frequency of the short (S) allele at 5-HTTLPR was significantly associated with AD [odds ratio (OR) = 1.18, 95% CI = 1.03–1.33). Moreover, a greater association with the S allele was seen among individuals with AD complicated by either a co-morbid psychiatric condition or an early-onset or more severe AD subtype [OR = 1.34 (95% CI = 1.11–1.63)]. Allelic variation at 5-HTTLPR contributes to risk for AD, with the greatest effect observed among individuals with a co-occurring clinical feature. © 2004 Wiley-Liss, Inc.

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