Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia
Version of Record online: 27 APR 2005
Copyright © 2005 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 136B, Issue 1, pages 8–11, 5 July 2005
How to Cite
Hong, L. E., Wonodi, I., Avila, M. T., Buchanan, R. W., McMahon, R. P., Mitchell, B. D., Stine, O. C., Carpenter, W. T. and Thaker, G. K. (2005), Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia. Am. J. Med. Genet., 136B: 8–11. doi: 10.1002/ajmg.b.30181
- Issue online: 28 JUN 2005
- Version of Record online: 27 APR 2005
- Manuscript Accepted: 22 FEB 2005
- Manuscript Received: 10 JUL 2004
- NIMH. Grant Numbers: MH68282, 49826, 67014, 70644, 68580
- General Clinical Research Center. Grant Number: M01-RR16500
- negative symptom;
A previous study has shown an association between the *2236T > C allele polymorphism of the dihydropyrimidinase-related protein 2 (DRP-2) gene and schizophrenia in a Japanese sample [Nakata et al. (2003); Biological Psychiatry 53:571–576]. DRP-2 is an important molecule in guiding neuronal development and its gene is located in 8p21, a chromosomal region that was previously shown to have significant linkage to schizophrenia and to several deficit symptoms of schizophrenia. We compared the frequency of the DRP-2 *2236T > C polymorphism between subjects with (n = 117) and without (n = 72) schizophrenia, and then further evaluated whether the association was specific for the deficit (n = 24) and nondeficit (n = 93) forms of schizophrenia. In both Caucasians and African-Americans, the C allele occurred more frequently in schizophrenia cases than controls, with this difference achieving statistical significance in Caucasians (C allele frequency: 42.0% in cases vs. 25.0% in controls, P = 0.014) but not African Americans (52.6% in cases vs. 50.0% in controls, P = 0.93). In Caucasians, the frequency of the C allele was significantly higher in both the deficit (allele frequency 53.3%, P = 0.009) and nondeficit (39.2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia. © 2005 Wiley-Liss, Inc.