Validation of population-based ADHD subtypes and identification of three clinically impaired subtypes
Article first published online: 8 MAR 2006
Copyright © 2006 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 141B, Issue 3, pages 312–318, 5 April 2006
How to Cite
Volk, H. E., Henderson, C., Neuman, R. J. and Todd, R. D. (2006), Validation of population-based ADHD subtypes and identification of three clinically impaired subtypes. Am. J. Med. Genet., 141B: 312–318. doi: 10.1002/ajmg.b.30299
- Issue published online: 27 MAR 2006
- Article first published online: 8 MAR 2006
- Manuscript Accepted: 22 DEC 2005
- Manuscript Received: 16 SEP 2005
- NIH. Grant Numbers: MH52813(R.D.T.), MH074272(H.E.V.)
- attention deficit hyperactivity disorder (ADHD);
- Child Behavior Checklist (CBCL);
- latent class analysis;
Statistically based classification methods have successfully refined ADHD into homogenous and heritable subtypes. External validity and impairment of these subtypes was examined using the Child Behavior Checklist (CBCL). We compared mean CBCL syndrome and competency t-scores across ADHD subtypes defined by latent class analysis in a sample of 1,346 individual twins from Missouri. The potential for comorbidity with conduct disorder (CD), oppositional defiant disorder (ODD), or major depression (MD) to increase impairment in specific ADHD subtypes was also examined. CBCL profiles confirm differences in severity, with more severe classes having increased syndrome scale and decreased competency scale CBCL scores. Clinically significant impairment was found for severe inattentive and combined subtypes and the mild combined subtype. Overall, the presence of comorbid CD, ODD, or MD did not result in increased ADHD subtype impairment. CBCL scores distinguish impairment in ADHD subtypes created through LCA. Comorbidity with CD, ODD, or MD does not significantly increase impairment among ADHD subtypes. The mild combined ADHD subtype represents a clinically significant but under-studied form of ADHD. © 2006 Wiley-Liss, Inc.