Please cite this article as follows: Light KJ, Joyce PR, Luty SE, Mulder RT, Frampton CMA, Joyce LRM, Miller AL, Kennedy MA. 2006. Preliminary Evidence for an Association Between a Dopamine D3 Receptor Gene Variant and Obsessive-Compulsive Personality Disorder in Patients With Major Depression. Am J Med Genet Part B 141B:409–413.
Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression†
Article first published online: 31 MAR 2006
Copyright © 2006 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 141B, Issue 4, pages 409–413, 5 June 2006
How to Cite
Light, K. J., Joyce, P. R., Luty, S. E., Mulder, R. T., Frampton, C. M.A., Joyce, L. R.M., Miller, A. L. and Kennedy, M. A. (2006), Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression. Am. J. Med. Genet., 141B: 409–413. doi: 10.1002/ajmg.b.30308
- Issue published online: 19 MAY 2006
- Article first published online: 31 MAR 2006
- Manuscript Accepted: 5 JAN 2006
- Manuscript Received: 27 SEP 2005
- Health Research Council of New Zealand
- dopamine D3 receptor gene;
- obsessive-compulsive personality disorder
We have previously reported that the Ser9Gly dopamine D3 receptor (DRD3) polymorphism was associated with increased rates of obsessive-compulsive personality disorder (OCPD) symptomology. We tested the replicability of this association within a further two independent groups of individuals with a history of depression, from a clinical sample (n = 149) and a family study (n = 213). The data from the replication samples and the original sample, within which the association was found, were compiled within a meta-analysis. Although the independent samples did not replicate the original finding, the meta-analysis elucidated significant evidence supporting the association. An individual with Gly/Gly genotype is 2.4 (P = 0.017) times more likely to be diagnosed with OCPD. Male gender was also found to be a significant predictor of OCPD diagnosis (OR = 2.82, P = 0.001). An exploration of an association of DRD3 with Axis I anxiety disorder diagnoses and Temperament and Character Inventory (TCI) traits, in particular persistence, revealed no support for an association. We conclude that DRD3 may contribute to the development of OCPD. © 2006 Wiley-Liss, Inc.