Genetic overlap between P300, P50, and duration mismatch negativity

Authors

  • Mei Hua Hall,

    Corresponding author
    1. Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, London, United Kingdom
    2. Division of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
    • Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, PO80, De Crespigny Park, London SE5 8AF, United Kingdom.
    Search for more papers by this author
  • Katja Schulze,

    1. Division of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
    Search for more papers by this author
  • Elvira Bramon,

    1. Division of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
    Search for more papers by this author
  • Robin M. Murray,

    1. Division of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
    Search for more papers by this author
  • Pak Sham,

    1. Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, London, United Kingdom
    2. Department of Psychiatry, Genome Research Centre, University of Hong Kong, Hong Kong
    Search for more papers by this author
  • Frühling Rijsdijk

    1. Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, London, United Kingdom
    Search for more papers by this author

  • Please cite this article as follows: Hall MH, Schulze K, Bramon E, Murray RM, Sham P, Rijsdijk F. 2006. Genetic Overlap Between P300, P50, and Duration Mismatch Negativity. Am J Med Genet Part B 141B:336–343.

Abstract

Mismatch Negativity (MMN), P300, and P50 suppression event-related potential (ERP) components measure intermediate stages of information processing but little is known of how they relate to each other genetically. The present study used multivariate genetic model fitting analytic techniques in 46 monozygotic and 32 dizygotic twin pairs. P300, P50 suppression, and MMN were recorded using a 19-channel electroencephalograph (EEG). Zygosity was determined using DNA genotyping. Little evidence for either genetic or environmental association between each of the three ERP paradigms was found. This result suggests that P300, MMN, and P50 suppression serve to evaluate different brain information processing functions that may be mediated by distinct neurobiological mechanisms which in turn are influenced by different sets of genes. Within paradigm, P300 amplitude and latency shared about half of their genetic effects. © 2006 Wiley-Liss, Inc.

Ancillary