Please cite this article as follows: Leyfer OT, Woodruff-Borden J, Klein-Tasman BP, Fricke JS, Mervis CB. 2006. Prevalence of Psychiatric Disorders in 4 to 16-Year-Olds With Williams Syndrome. Am J Med Genet Part B 141B:615–622.
Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome†
Version of Record online: 5 JUL 2006
Copyright © 2006 Wiley-Liss, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 141B, Issue 6, pages 615–622, 5 September 2006
How to Cite
Leyfer, O. T., Woodruff-Borden, J., Klein-Tasman, B. P., Fricke, J. S. and Mervis, C. B. (2006), Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome. Am. J. Med. Genet., 141B: 615–622. doi: 10.1002/ajmg.b.30344
- Issue online: 17 AUG 2006
- Version of Record online: 5 JUL 2006
- Manuscript Accepted: 30 APR 2006
- Manuscript Received: 19 DEC 2005
- National Institute of Neurological Disorders and Stroke. Grant Number: R01 NS35102
- National Institute of Child Health and Human Development (to C.B.M.). Grant Number: R37 HD29957
- Williams syndrome;
- mental retardation;
- intellectual disability
The prevalence of a range of DSM-IV psychiatric disorders in a sample of 119 4–16-year-old children with Williams syndrome (WS) was assessed using a structured diagnostic interview with their parents. Most children (80.7%) met criteria for at least one DSM-IV diagnosis. The most prevalent diagnoses were Attention Deficit/Hyperactivity Disorder (ADHD; 64.7%) and Specific Phobia (53.8%). There was a significant shift in Predominant Type of ADHD as a function of CA, from Combined for the youngest group (ages 4–6 years) to Inattentive for the oldest group (ages 11–16 years). The prevalence of Generalized Anxiety Disorder (GAD) increased significantly with age. These findings are another step toward defining the behavioral phenotype of WS. © 2006 Wiley-Liss, Inc.